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dc.contributor.authorMedger, K.
dc.contributor.authorBennett, N.C.
dc.contributor.authorChimimba, C.T.
dc.contributor.authorOosthuizen, M.K.
dc.contributor.authorMikkelsen, J.D.
dc.contributor.authorCoen, C.W.
dc.date.accessioned2018-11-16T11:01:09Z
dc.date.available2018-11-16T11:01:09Z
dc.date.issued2018
dc.identifier.citationMedger, K.; Bennett, N.C.; Chimimba, C.T.; Oosthuizen, M.K.; Mikkelsen, J.C.; Coen, C.W. (2018) Ananlysis of gonadotrophin-releasing hormone-1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant-shrew (Elephantulus myurus). Journal of Comparative Neurology, 526(15): 2388-2405en_ZA
dc.identifier.issn0021-9967en_ZA
dc.identifier.urihttp://hdl.handle.net/123456789/2538
dc.description.abstractOf the 18 sub-Saharan elephant-shrew species, only eastern rock elephant-shrews reproduce seasonally throughout their distribution, a process seemingly independent of photoperiod. The present study characterizes gonadal status and location/intensity of gonadotrophin-releasing hormone-1 (GnRH-1) and kisspeptin immunoreactivities in this polyovulating species in the breeding and nonbreeding seasons. GnRH-1-immunoreactive (ir) cell bodies are predominantly in the medial septum, diagonal band, and medial preoptic area; processes are generally sparse except in the external median eminence. Kisspeptin-ir cell bodies are detected only within the arcuate nucleus; the density of processes is generally low, except in the septohypothalamic nucleus, ventromedial bed nucleus of the stria terminalis, arcuate nucleus, and internal and external median eminence. Kisspeptin-ir processes are negligible at locations containing GnRH-1-ir cell bodies. The external median eminence is the only site with conspicuously overlapping distributions of the respective immunoreactivities and, accordingly, a putative site for kisspeptin's regulation of GnRH-1 release in this species. In the nonbreeding season in males, there is an increase in the rostral population of GnRH-1-ir cell bodies and density of GnRH-1-ir processes in the median eminence. In both sexes, the breeding season is associated with increased kisspeptin-ir process density in the rostral periventricular area of the third ventricle and arcuate nucleus; at the latter site, this is positively correlated with gonadal mass. Cross-species comparisons lead us to hypothesize differential mechanisms within these peptidergic systems: that increased GnRH-1 immunoreactivity during the nonbreeding season reflects increased accumulation with reduced release; that increased kisspeptin immunoreactivity during the breeding season reflects increased synthesis with increased release.en_ZA
dc.language.isoenen_ZA
dc.publisherWiley Periodicals Inc.en_ZA
dc.subjectAfrotheriaen_ZA
dc.subjectanteroventral periventricular nucleusen_ZA
dc.subjectarcuate nucleusen_ZA
dc.subjectgonadotrophin-releasing hormone-1en_ZA
dc.subjectkisspeptinen_ZA
dc.subjectRRID:AB_2315026en_ZA
dc.subjectRRID:AB_2631061en_ZA
dc.subjectRRID:AB_572248en_ZA
dc.subjectRRID:SCR_002865en_ZA
dc.subjectRRID:SCR_003070en_ZA
dc.subjectRRID:SCR_014199en_ZA
dc.subjectseasonal reproductionen_ZA
dc.titleAnanlysis of gonadotrophin-releasing hormone-1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant-shrew (Elephantulus myurus)en_ZA
dc.typeJournalArticlesen_ZA
dc.cibjournalJournal of Comparative Neurologyen_ZA
dc.cibprojectNAen_ZA


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